The ACE Study was testing whether preventing genital herpes outbreaks with twice-daily acyclovir among HIV negative people would prevent them from getting HIV.
Results from this study showed no evidence that taking twice-daily acyclovir prevented HIV infection in HIV negative people. Results did show, however, that acyclovir did reduce genital ulcers in people infected with HSV2, the virus that causes genital herpes.
Hearty thanks are due to the 180 men from the Bay Area who enrolled in this study. Without their dedication and willingness to volunteer, we would not have an answer to this very important question.
It is clear that sexually transmitted infections (STIs) like genital herpes are related to HIV risk, and studies will continue to look at how preventing and treating STIs may reduce the impact of HIV.
Click here to read more about the ACE Study results.
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